Nasal Polyps Study 2020 - How To Treat Nasal Polyps ?

This nasal polyps study was approved by the ethics committee of the Yamagata University Faculty of Medicine and conducted with informed consent from the patients. Forty-six patients who underwent functional endo¬scopic sinus surgery, septal surgery, or inferior tur- binectomy were enrolled for assessments involving immunohistochemistry, quantitative real-time polym-erase chain reaction (RT-PCR), and Western blotting . 

Patients were allocated to one of four groups: allergic rhinitis, chronic rhinosinusitis with nasal polyps, aspirin-induced asthma, or control. The control group consisted of patients who were undergoing septoplasty because of anatomic variations and who had no sinus disease; inferior turbinate mucosal samples were taken from these patients during sur¬gery. Chronic rhinosinusitis with nasal polyps was diagnosed according to the clinical criteria of Meltzer et al. on the basis of patient history, clinical examination, nasal endoscopy, and sinus computed tomography. 

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Diseased sinus mucosal tissue and nasal polyp tissue were collected during surgery. Subjects were excluded if they had received oral steroids or immunotherapy in the 3 months before surgery or if they had undergone previous sinus surgery

Periostin-positive staining was observed in the basement membrane, extracellular matrix, nasal polyp tissue, and infiltrating cells by means of immunohisto- chemical staining. Production of periostin protein was significantly greater in tissues from pa¬tients with allergic rhinitis (mean = 14.8), chronic rhinosinusitis with nasal polyps (mean = 32.4), or aspirin-induced asthma patients (mean = 32.5) than in control tissues (mean = 5.1) (P < 0.05)  ==> Patients with chronic rhinosinusitis or aspirin- induced asthma had significantly stronger protein production in their nasal polyps