How Dangerous Is Nasal Polyps ?


Chronic rhinosinusitis with nasal polyps ( nose polyps) is one of the most frequently encountered chronic nasal diseases, and the complexity of this condition in the presence of nasal polyps complicates the study of its etiological thera peutics. 

Patients  whose symptoms are refractory to treatment often develop nasal polyps. Growth of these polyps leads to obstruction of the sinonasal passages, and surgery may be necessary in advanced cases to remove the polyps to restore sinus ventilation. Proliferation and thickening of the mucosal epithelium, with focal squamous metaplasia, glandular hyperplasia, subepithelial fibrosis, and stromal edema with numerous blood vessels, have been histologically observed in nasal polyps.10 One of the most important characteristics of chronic rhinosinusitis is the prolonged and exaggerated inflammatory reaction in the paranasal mucous membranes.

 Samter’s triad is a condition diagnosed with aspirin-induced asthma in a subset of patients with chronic rhinosinusitis with nasal polyps, and it is characterized by nasal polyps, asthma, and aspirin in- tolerance.In individuals with aspirin-induced asthma, nonsteroidal anti-inflammatory agents, including aspirin, lead to immediate and severe bron- chospasm which requires urgent emergency treat- ment It is hypothesized that a common stimulus causes inflammation of both the sinonasal and the bronchopulmonary mucosa. Pendrin is an anion transporter that plays an impor-tant role in mucus production in nasal polyps patients. Mucus overproduction is a prominent feature of both bronchial asthma and chronic obstructive pulmonary disease and is a major determinant of morbidity and mortality in these diseases

Read more :  How to Cure Nasal Polyps Permanently and Naturally at Home ?


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Nasal Polyps Study 2020 - How To Treat Nasal Polyps ?

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This nasal polyps study was approved by the ethics committee of the Yamagata University Faculty of Medicine and conducted with informed consent from the patients. Forty-six patients who underwent functional endo¬scopic sinus surgery, septal surgery, or inferior tur- binectomy were enrolled for assessments involving immunohistochemistry, quantitative real-time polym-erase chain reaction (RT-PCR), and Western blotting .  Patients were allocated to one of four groups: allergic rhinitis, chronic rhinosinusitis with nasal polyps, aspirin-induced asthma, or control. The control group consisted of patients who were undergoing septoplasty because of anatomic variations and who had no sinus disease; inferior turbinate mucosal samples were taken from these patients during sur¬gery. Chronic rhinosinusitis with nasal polyps was diagnosed according to the clinical criteria of Meltzer et al. on the basis of patient history, clinical examination, nasal endoscopy, and sinus computed tomography.  Read
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